Compulsive drug use linked to sensitized ventral striatal dopamine transmission
Identifieur interne : 001332 ( Main/Exploration ); précédent : 001331; suivant : 001333Compulsive drug use linked to sensitized ventral striatal dopamine transmission
Auteurs : Andrew H. Evans [Royaume-Uni] ; Nicola Pavese [Royaume-Uni] ; Andrew D. Lawrence [Royaume-Uni] ; Yen F. Tai [Royaume-Uni] ; Silke Appel [Royaume-Uni] ; Miroslava Doder [Royaume-Uni] ; David J. Brooks [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Paola Piccini [Royaume-Uni]Source :
- Annals of Neurology [ 0364-5134 ] ; 2006-05.
Abstract
Objective: A small group of Parkinson's disease (PD) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical effects and fulfil core Diagnostic and Statistical Manual (of Mental Disorders) Fourth Edition criteria for substance dependence (dopamine dysregulation syndrome [DDS]). We aimed to evaluate levodopa‐induced dopamine neurotransmission in the striatum of patients with DDS compared with PD control patients. Methods: We used a two‐scan positron emission tomography protocol to calculate the percentage change in 11C‐raclopride binding potential from a baseline withdrawal (off drug) state to the binding potential after an oral dose of levodopa. We related the subjective effects of levodopa to the effects on endogenous dopamine release of a pharmacological challenge with levodopa in eight control PD patients and eight patients with DDS. Results: PD patients with DDS exhibited enhanced levodopa‐induced ventral striatal dopamine release compared with levodopa‐treated patients with PD not compulsively taking dopaminergic drugs. The sensitized ventral striatal dopamine neurotransmission produced by levodopa in these individuals correlated with self‐reported compulsive drug “wanting” but not “liking” and was related to heightened psychomotor activation (punding). Interpretation: This provides evidence that links sensitization of ventral striatal circuitry in humans to compulsive drug use. Ann Neurol 2006
Url:
DOI: 10.1002/ana.20822
Affiliations:
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We aimed to evaluate levodopa‐induced dopamine neurotransmission in the striatum of patients with DDS compared with PD control patients. Methods: We used a two‐scan positron emission tomography protocol to calculate the percentage change in 11C‐raclopride binding potential from a baseline withdrawal (off drug) state to the binding potential after an oral dose of levodopa. We related the subjective effects of levodopa to the effects on endogenous dopamine release of a pharmacological challenge with levodopa in eight control PD patients and eight patients with DDS. Results: PD patients with DDS exhibited enhanced levodopa‐induced ventral striatal dopamine release compared with levodopa‐treated patients with PD not compulsively taking dopaminergic drugs. The sensitized ventral striatal dopamine neurotransmission produced by levodopa in these individuals correlated with self‐reported compulsive drug “wanting” but not “liking” and was related to heightened psychomotor activation (punding). Interpretation: This provides evidence that links sensitization of ventral striatal circuitry in humans to compulsive drug use. Ann Neurol 2006</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H." last="Evans">Andrew H. Evans</name></region><name sortKey="Appel, Silke" sort="Appel, Silke" uniqKey="Appel S" first="Silke" last="Appel">Silke Appel</name><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><name sortKey="Doder, Miroslava" sort="Doder, Miroslava" uniqKey="Doder M" first="Miroslava" last="Doder">Miroslava Doder</name><name sortKey="Lawrence, Andrew D" sort="Lawrence, Andrew D" uniqKey="Lawrence A" first="Andrew D." last="Lawrence">Andrew D. Lawrence</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Pavese, Nicola" sort="Pavese, Nicola" uniqKey="Pavese N" first="Nicola" last="Pavese">Nicola Pavese</name><name sortKey="Piccini, Paola" sort="Piccini, Paola" uniqKey="Piccini P" first="Paola" last="Piccini">Paola Piccini</name><name sortKey="Tai, Yen F" sort="Tai, Yen F" uniqKey="Tai Y" first="Yen F." last="Tai">Yen F. Tai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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